Chrome (8.0.522.237) isn't rendering a linked CSS file from an ASP.NET WebResource.axd (an embedded resource).
The following warning appears in Developer Tools - Resources:
Resource interpreted as stylesheet but transferred with MIME type text/plain.
In this case the issue was with the WebResource reference in the AssemblyInfo.cs
[assembly: WebResource("SampleNamespace.SampleCss.css", "text-css", PerformSubstitution = true)]
Should have been:
[assembly: WebResource("SampleNamespace.SampleCss.css", "text/css", PerformSubstitution = true)]